The competition will offer Dave Challinor the chance to look at members of the squad whose first team chances have been limited since he took charge seven games ago.
While wholesale changes aren’t expected, injuries and the fact several players played 120-minutes in Tuesday night’s FA Cup victory over Exeter City should see several new faces come into the starting line-up at the CNG Stadium today.
Scroll down and click through the page to see our predicted line-up ahead of the match...
1. GK - Ben Killip
Despite signing goalkeepers Dimi Konstantopoulos and Mitchell Beeney on non-contract terms over the past week or so, Pools' number one isn't expected to drop out of the side having kept a well-earned clean sheet on Tuesday night. Photo: Frank Reid
2. LWB - Romoney Crichlow-Noble
Could be handed his first start since August after impressing off the bench on Tuesday night. Photo: Paul Paxford
3. CB - Michael Raynes
A lack of available defensive cover could see the veteran play his 29th match of the campaign today on Harrogate's 3G pitch. Photo: Frank Reid
4. CB - Fraser Kerr
Was solid alongside Raynes on Tuesday night as Pools put in a great defensive display to earn their first clean sheet under Dave Challinor. Photo: Paul Paxford